Pulmonary deposition and clearance of aerosolized interferon
نویسندگان
چکیده
منابع مشابه
Pulmonary gas-exchange analysis by using simultaneous deposition of aerosolized and injected microspheres.
Numerical methods for determining end-capillary gas contents for ventilation-to-perfusion ratios were first developed in the late 1960s. In the 1970s these methods were applied to validate distributions of ventilation-to-perfusion ratios measured by the multiple inert-gas-elimination technique. We combined numerical gas analysis and fluorescent-microsphere measurements of ventilation and perfus...
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We have often, and over a long time, thought of the "small airways" as a mystery zone or a quiet zone [1]. Relative to central bronchial generations, the total crosssectional area of each bronchiolar generation is large. Airflow resistance should in consequence be low. Considerable changes due to disease could, thus, occur with little chance of being detected by conventional lung function testi...
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The effect of removal of sialic acid on the survival of rabbit serum and urinary interferon (IF) has been investigated in isolate, perfused rabbit liver preparations. In contrast with native IF, which may be already partially desialylated. IF freed of 80 to 90% of its sialic acid was rapidly cleared from the perfusate of normal livers, or livers pre-treated with actinomycin D. The results sugge...
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Theoretical models of respiratory tract deposition of inhaled particles are compared to experimental studies of deposition patterns in humans and animals, as governed principally by particle size, density, respiratory rate and flow parameters. Various models of inhaled particle deposition make use of approximations of the respiratory tract to predict fractional deposition caused by fundamental ...
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As freon is limited in its use as a generator for aerosol inhalation, powder particles are used as an alternative for inhalation therapy. The pulmonary deposition and clearance of inhaled powder particles was studied by positron emission tomography (PET) in ten patients with chronic obstructive pulmonary disease (COPD) and in five normal controls. The powder, 5 microm in mean diameter, was wate...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1984
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.25.6.729